|
KMID : 1004820140150010001
|
|
Journal of Biomedical Research
2014 Volume.15 No. 1 p.1 ~ p.6
|
|
|
Therapeutic effects of combination of Galla rhois extract and Sodium chlorate on Mice infected with Brucella abortus
|
|
Cha Chun-Nam
Hong Il-Hwa
Yu Eun-Ah
Park Eun-Kee
Yoo Chang-Yeol
Kim Suk
Lee Hu-Jang
|
|
|
Abstract
|
|
|
|
This study investigated the therapeutic effects of Galla rhois (GR) ethanol extract (GRE), sodium chlorate (SC), and a combination of GRE and SC on mice infected with Brucella abortus (B. abortus). Mice were infected intraperitoneally with B. abortus and then treated with GRE, SC, and a combination GRE and SC in drinking water for 14 days. Then, serum antibodies were used in a tube agglutination test (TAT), after which the weight and CFUs from each spleen were measured. In addition, histopathological changes in each liver were examined at 14 days post-infection. At 14 days post-infection, negative reactions of serum antibodies in PC (positive control), SCT (SC 1.6 g/L drinking water), GRT (GRE 200 mg/L drinking water), and GST (GRE 200 mg + SC 1.6 g/L drinking water) were 0, 40, 60, and 80%, respectively. The average spleen weight was not significantly different between the groups. At 14 days post-infection, bacterial numbers in all treated groups were significantly lower compared to to that of the PC (GRT and SCT, P<0.05; GST, P<0.001). In terms of histopathological changes in the livers, there were numerous multifocal microgranulomas in the PC, whereas this number successively decreased in the SCT, GRT, and GST groups. Conclusively, a combination of GRE and SC exhibits therapeutic effects on mice infected with B. abortus. These results suggest the potential efficacy of a mixture of GRE and SC in the treatment of brucellosis.
|
|
|
KEYWORD
|
|
|
Brucella abortus, Galla rhois, sodium chlorate, combination, mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|